Synthesis and functionalization of N-sulfinyl imines: sonogashira reaction and copper-catalyzed azide-alkyne cycloaddition

ABSTRACT

A small library of novel molecules was generated using a rapid and efficient methodology for the synthesis of N-sulfinyl imine triazole compounds. The process involves a coupling step from the Sonogashira cross-coupling reaction and then, in a one-step reaction, deprotection of the trimethylsilyl group and triazole heterocyclic ring formation using a microwave reactor.