NGF prevents changes in rat brain glutathione-related enzymes following transection of the septohippocampal pathway
La Habana; s.n; 1999. 6 p. graf.
Não convencional
em Inglês
| CUMED
| ID: cum-16425
Biblioteca responsável:
CU1
Localização: Centro Internacional de Restauración Neurológica
ABSTRACT
The activities of the enzymes glutathione reductase (GRD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) were studied in several rat brain areas following the aspirative transection of the septohippocampal pathway (fimbria fornix) and the administration of nerve growth factor (NGF) or cytochrome c. One group of animals remained untreated. This lesion resulted in a decreased hippocampal GRD and septal GST activities, as well as, in an increase in GPX activity from the frontal cortex, striatum, and septum, NGF prevented the lesion-induced changes in hippocampal GRD and septal GPX. These findings show that the insult resulting from the aspiration of the fimbria fornix bundle involves modifications in glutathione-related enzymes, and, therefore, in the antioxidant status of brain tissue. These changes in gluthatione metabolism could be a consequence of the oxidative damage to GRD and GST protein or represent a compensatory response of GPX to the oxidative threat. The restirubg effects if BGF ib aktered ebztne activities are possibly linked to its known neuroprotective action(AU)
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Bases de dados nacionais
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Cuba
Base de dados:
CUMED
Assunto principal:
Ratos
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Modelos Animais de Doenças
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Glutationa
/
Hipocampo
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Fatores de Crescimento Neural
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
1999
Tipo de documento:
Não convencional