Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression / Impacto virológico, inmunológico y clínico del cambio de inhibidores de proteasa a terapia con nevirapina o efavirenz en pacientes infactados con el VIH que presentan una supresión viral prolongada
Clin Infect Dis
; 34(4)feb. 2002. tab, graf
Artigo
em Inglês
| CUMED
| ID: cum-39443
Biblioteca responsável:
CU425.1
ABSTRACT
Seventy-seven subjects infected with human immunodeficiency virus were randomized to switch from protease inhibitor (PI) therapy to nevirapine therapy (group A; n=26) or to efavirenz therapy (group B; n=25) or to continue PI therapy (group C; n=26), At month 12, viral suppression had been maintained in 96 of patients in group A, 92 of patients in group B, and 92 of patients in group C. A significant increase in the CD4(+) level was observed in all 3 groups, In group A, lipid profiles improved, whereas levels of gamma-glutamiltransferase and alanine aminotransferase significantly increased; 1 subject interrupted treatment because of hepatotoxicity. In group B, an increase in gamma-glutamiltransferase levels was also observed, and 3 patients interrupted treatment because of central nervous system symptoms, Two patients in group C withdrew therapy, Quality of life significantly improved for groups A and B, In patients receiving effective PI-based therapy, the replacement of the PI with either nevirapine or efavirenz is safe and virologically effective(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Cuba
Base de dados:
CUMED
Assunto principal:
Infecções por HIV
/
Inibidores da Protease de HIV
/
Nevirapina
/
Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Ensaio clínico controlado
Aspecto:
Preferência do paciente
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin Infect Dis
Ano de publicação:
2002
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Universitario Arnaldo Milián Castro/Cuba
/
University Hospital/España