Disgregantes y superdisgregantes. Estudio de los mecanismos de disgregación / Disintegrants and superdisintegrants. Study of disintegration mechanisms

RESUMEN

La disgregación de los comprimidos es un paso previo fundamental para la liberación del principio activo, pudiendo influir en su biodisponibilidad y efecto terapéutico. Los disgregantes constituyen un componente de gran importancia en la formulación de comprimidos, pero son tan variados los mecanismos por los que ejercen su acción, que no siempre es fácil la elección del disgregante idóneo. Dentro de los distintos mecanismos de disgregación propuestos por diversos autores, destacan el hinchamiento de las partículas de disgregantes y la porosidad o red capilar porosa. En este trabajo se revisan los diferentes mecanismos de acción de los disgregantes así como los factores susceptibles de influir en el proceso de disgregación

ABSTRACT

The disintegration of tablets is a fundamentalprevious step for the liberation of the activeprinciple from the pharmaceutical dosage form,being able to influence in its bioavailability and therapeutic effect. The disgregantes constitute a component of great importance in the tablet formulation, but so the mechanisms are varied by which they exert his action, that not alwaysis easy the election of the suitable disintegrant. Within the different mechanisms of disintegration proposed by diverse authors, they emphasize the swelling of particles of disintegrants and the porosity or porous hair network. In this work the different mechanisms from action of the disgregantes as well as the factors susceptible are reviewed to influence in the disintegration process The disintegration of tablets is a fundamental previous step for the liberation of the active principle from the pharmaceutical dosage form, being able to influence in its bioavailability and therapeutic effect. The disgregantes constitute a component of great importance in the tablet formulation, but so the mechanisms are varied by which they exert his action, that not always is easy the election of the suitable disintegrant. Within the different mechanisms of disintegration proposed by diverse authors, they emphasize the swelling of particles of disintegrants and the porosity or porous hair network. In this work the different mechanisms from action of the disgregantes as well as the factors susceptible are reviewed to influence in the disintegration process