Results of radiotherapy in primary cutaneous lymphoma

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ABSTRACT

Introduction. Multiple therapeutic strategies havebeen proposed for the management of primary cutaneouslymphomas. We report the outcome dataand therapeutic response of a group of patientstreated with local radiotherapy.Material and methods. Twenty seven patientswith diagnostic of cutaneous lymphoma and treatedwith local radiation were evaluated for clinicalresponse. Thirteen cases corresponded to cutaneousT-cell lymphomas (CTCL) and 14 to cutaneousB-cell lymphomas (CBCL). Orthovoltage radiotherapyof 100 Kv was used and total dose ofradiation ranged from 15 to 30 Gy (mean 24 Gy;median 20 Gy).Results. The immediate response to the treatmentwas satisfactory in all cases. In 24 patients (89%)complete response was obtained in the irradiatedlesion and in 3 cases (11%) the response was partial.With a mean follow-up of 25.4 months (range1-100 months) the overall response rate was 96.3%.Fourteen patients (52%) were alive without evidenceof disease (6 CTCL and 8 CBCL), 5 patients(18%) retained cutaneous disease or had systemicprogression (3 CTCL and 2 CBCL) and 8 patientsdied (30%). In 7 patients lymphoma progressionwas the factor leading to death (26%) and in onepatient the cause was not related with the disease.Conclusions. Radiotherapy was demonstrated tobe able to induce clinical remission of primary cutaneouslymphomas