Plasminogen activator inhibitor-1 and angiotensin converting enzyme gene polymorphisms in Turkish asthmatic children
Allergol. immunopatol
; 41(1): 11-16, ene.-feb. 2013. tab
Artigo
em Inglês
| IBECS
| ID: ibc-109462
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
Polymorphisms of plasminogen activator inhibitor-1 (PAI-1) and angiotensin-converting enzyme (ACE) genes have been implicated in susceptibility to asthma. In this study, we aimed to investigate whether there was any association between childhood asthma and polymorphisms of the PAI-1 and ACE genes.Methods:
Two hundred and three Turkish children aged 515 years, including 102 asthmatic patients and 101 healthy control subjects were included in this study. The asthma group was divided into two groups as follows Group I Asthmatic children with positive family history for atopy (n=53), Group II Asthmatic children without any family history for atopy (n=49). One hundred and twenty-eight atopic family members were also included in the study. The insertion/deletion (I/D) polymorphism of the ACE and PAI-1 4G/5G gene polymorphisms was carried out by polymerase chain reaction.Results:
The prevalence of the PAI-1 4G allele was significantly greater in asthmatic children compared to control group (p<0.05, OR 1.64 (1.112.43)) but there was no significant relation between ACE I/D genotypes and childhood asthma. No significant difference was detected between Groups I and II in terms of these ACE and PAI-1 genotypes and allele frequencies. No significant relationship was found between both gene polymorphisms and total serum IgE and skin prick test results.Conclusion:
It has been established that PAI-1 4G allele may be a genetic risk factor for childhood asthma but ACE gene I/D polymorphisms do not play a role in the development of asthma in the sample of Turkish children(AU)
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Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Asma
/
Inibidor 1 de Ativador de Plasminogênio
/
Receptor Tipo 1 de Angiotensina
/
Antagonistas de Receptores de Angiotensina
Tipo de estudo:
Fatores de risco
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Dokuz Eylul University/Turkey