Genetic basis of dental agenesis - molecular genetics patterning clinical dentistry
Med. oral patol. oral cir. bucal (Internet)
; 19(2): e112-e119, mar. 2014. tab
Artigo
em Inglês
| IBECS
| ID: ibc-121349
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Tooth agenesis is one of the most common congenital malformations in humans. Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be associated with a syndrome (syndromic hypodontia), highlighting the heterogeneity of the condition. Though much progress has been made to identify the developmental basis of tooth formation, knowledge of the etiological basis of inherited tooth loss is still lacking. To date, the mutation spectra of non-syndromic form of familial and sporadic tooth agenesis in humans have revealed defects in various such genes that encode transcription factors, MSX1 and PAX9 or genes that code for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1). The aim of this paper is to review the current literature on the molecular mechanisms responsible for selective hypodontia in humans and to present a detailed overview of causative genes and syndromes associated with hypodontia
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Anormalidades Dentárias
/
Anodontia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Maulana Azad Institute of Dental Sciences/India
/
Safdarjang Hospital/India