Changes in serum parameters associated with iron metabolism in male rat exposed to lead
J. physiol. biochem
; 69(2): 297-304, jun. 2013.
Artigo
em Inglês
| IBECS
| ID: ibc-121977
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Due to the severe hazardous influences of lead (Pb2+) on iron-related diseases, the effects of Pb2+ on serum parameters associated with iron metabolism have been studied in this project. Male Wistar rats weighing 200250 g were treated with Pb2+ for the short and long period of times. The animals received daily intraperitoneal injection of 100 mg Pb2+ kg−1 body weight (BW) for 5 days and 4 mg kg−1 BW of Pb2+ for 30 and 45 days, respectively. The results show that when animals were treated with both low and high concentrations of Pb2+, serum iron concentration decreased markedly, by 23.2, 32.8, and 39.9 %, while the sera TIBC and transferrin concentrations increased significantly (p < 0.05). Following short- and long-term exposures to Pb2+, the percentage of serum transferrin saturation was also decreased in comparison with the untreated control group (p < 0.05). Concentrations of serum copper and ceruloplasmin following Pb2+ treatments also reduced significantly (p < 0.05). The percentage of hematocrit and hemoglobin levels was reduced (p < 0.05) in all Pb2+-treated animals in comparison with the controls. These results suggest that Pb2+ changes the serum parameters related to iron metabolism, which may play an important role in producing iron-related diseases (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Envenenamento não Intencional
/
Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo
Base de dados:
IBECS
Assunto principal:
Hemoglobinas
/
Hematócrito
/
Ferro
/
Intoxicação por Chumbo
Tipo de estudo:
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Isfahan University of Medical Science/Iran
/
Islamic Azad University/Iran