Effect of dietary fiber of Rihane barley grains and azoxymethane on serum and liver lipid variables in Wistar rats
J. physiol. biochem
; 67(1): 27-34, mar. 2011.
Artigo
em Inglês
| IBECS
| ID: ibc-122631
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
No disponible
ABSTRACT
The aim of the present study is to evaluate the effects of diet enriched with dietary fiber of barley variety Rihane and azoxymethane on serum and liver lipid variables in male rats. Forty male rats were divided into four groups and fed on control diet or experimental diet that contained control enriched with dietary fiber of barley variety Rihane. Animals were injected with saline (controls) or azoxymethane (20 mg/kg body weight s.c.) at 7 and 8 weeks of age. The experimental diet significantly decreased cholesterol level compared with the control diet. Rats fed with BR diet significantly increased the serum high-density lipoprotein (HDL) cholesterol and significantly decreased low-density lipoprotein (LDL) cholesterol concentrations. The experimental diet decreased the atherogenic index (p < 0.05) compared with the control diet. Whereas the azoxymethane induced a significant increase of liver lipid, serum LDL and triglyceride concentrations, but it caused a significant reduction of HDL. Consequently, the ratio of HDL/TC decreased significantly compared with the control (p < 0.05). Accordingly, these results indicated that the diet enriched with dietary fiber of barley variety Rihane could be effective in decreasing the atherogenic risk factors in rats whereas the use of the azoxymethane as colon-specific carcinogen substance altered the lipid metabolism (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Azoximetano
/
Hordeum
/
Fibras na Dieta
/
Neoplasias do Colo
/
Aterosclerose
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
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Estudo prognóstico
/
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Faculté de Médecine de Monastir/Tunisia
/
Hôpital Farhat Hachad Sousse/Tunisia
/
INRA-Tunisia/Tunisia
/
INRAT/Tunisia
/
Institut Supérieur de Biotechnologie de Monastir/Tunisia