Bauhinia bauhinioides cruzipain inhibitor reduces endothelial proliferation and induces an increase of the intracellular Ca2+ concentration
J. physiol. biochem
; 66(4): 283-290, dic. 2010.
Artigo
em Inglês
| IBECS
| ID: ibc-122815
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
No disponible
ABSTRACT
Proteinase inhibitors, isolated from different types of Bauhinia, have an effect on apoptosis, angiogenesis and inflammation. The Bauhinia bauhinioides cruzipain inhibitor (BbCI) is a Kunitz-type inhibitor and inactivates the cysteine proteinases cruzipain and cruzain from Trypanosoma cruzi. Cruzipain and tissue kallikrein have similar biochemical properties, e.g. the proteolytic cleavage of the kininogen precursor of lys-bradykinin. Tissue kallikrein stimulation in endothelial cells causes migration and capillary tube formation. The aim of this study was to examine whether theantiproliferative effect of BbCI is dependent on changes of the intracellular calcium concentration and membrane hyperpolarization. Endothelial cells were isolated from human umbilical cord veins(HUVEC). For proliferation experiments, HUVEC were incubated with (..)(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doença de Chagas
Base de dados:
IBECS
Assunto principal:
Inibidores de Cisteína Proteinase
/
Apoptose
/
Bauhinia
/
Proteínas Sensoras de Cálcio Intracelular
/
Inflamação
/
Neovascularização Patológica
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
Justus-Liebig-University of Giessen/Germany
/
Justus-Liebig-University of Giessen, Klinikstrasse/Germany
/
Universidade Federal de São Paulo/Brazil