Prostate carcinoma and stem cells
Clin. transl. oncol. (Print)
; 9(2): 66-76, feb. 2007. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-123270
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the mature tissue. Stem cells and tumour cells have many similar features, including infinite lifespan, self-renewal, multidrug resistance, telomerase expression and, in the instance of the prostate, androgen independence. Evidence supports a role for stem cells in the etiology of many types of cancer. The evolution of androgen-independent prostate carcinoma may reflect the emergence of stemlike prostate tumour cells. Because cancer may be a disease of stem cell lineages and Shh-Gli signalling controls the behaviour of precursors and of cells with stem cell properties in the mammalian tissues, prostate cancer might derive from inappropriate expansion of prostatic epithelial stem cell lineages caused by abnormal Shh-Gli function. This review attempts to integrate these recent results (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Próstata
/
Células-Tronco Neoplásicas
/
Biomarcadores Tumorais
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Regulação Neoplásica da Expressão Gênica
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complejo Hospitalario Universitario/Spain
/
Lisbon University/Portugal
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University Hospital of Guadalajara/Spain
/
University of La Coruña/Spain