Risk factors of local relapse in breast cancer: the importance of age
Clin. transl. oncol. (Print)
; 9(2): 110-116, feb. 2007. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123276
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
PURPOSE:
The objective of the present analysis is to know what risk factors affect local relapse in breast cancer. METHODS AND MATERIALS A total of 1165 patients diagnosed with early breast cancer were included. Boost dose was modulated in the presence of risk factors. Patients with one risk factor received a boost of 10 Gy, while 20 Gy was administered in those with two risk factors.RESULTS:
Median follow-up was of 60 months. Mean age of patients was 56.7+/-10.8 years. Local risk factors were present in 82.8% of patients. The probability of remaining free of local recurrence at 5 and 10 years is 97.7% (CI 95% 96.7-98.7) and 94.5% (CI 95% 92.1-96.9). Only age showed an impact in local relapse on multivariate analysis. Patients 40 years or younger had a relative risk of local relapse of 5.27 and patients 41-50 of 3.7 with respect to patients older than 50 years.CONCLUSION:
Patients 40 years or younger have a higher risk of local failure than older patients. Other risk factors such as tumour size, intraductal carcinoma or margin status could be masked by an increase of radiation dose (AU)
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama
/
Adenocarcinoma
/
Recidiva Local de Neoplasia
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universitat Pompeu Fabra/Spain