Non-invasive genetic imaging for molecular and cell therapies of cancer
Clin. transl. oncol. (Print)
; 9(11): 703-714, nov. 2007. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-123380
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Gene therapy is a very attractive strategy in experimental cancer therapy. Ideally, the approach aims to deliver therapeutic genes selectively to cancer cells. However, progress in the improvement of gene therapy formulations has been hampered by difficulties in measuring transgene delivery and in quantifying transgene expression in vivo. In clinical trials, endpoints rely almost exclusively on the analysis of biopsies, which provide limited information. Non-invasive monitoring of gene delivery and expression is a very attractive approach as it can be repeated over time in the same patient to provide spatiotemporal information on gene expression on a whole body scale. Thus, imaging methods can uniquely provide researchers and clinicians the ability to directly and serially assess morphological, functional and metabolic changes consequent to molecular and cellular based therapies. This review highlights the various methods currently being developed in preclinical models (AU)
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Diagnóstico por Imagem
/
Ensaios Clínicos como Assunto
/
Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
INSERM. CIC-04 Biotherapies Héapatiques/France
/
Imperial College London/UK
/
Universidad Francisco de Vitoria/Spain