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Clinical course of high-grade glioma patients with a "biopsy-only" surgical approach: a need for individualised treatment
Balaña, C; Capellades, J; Teixidor, P; Roussos, I; Ballester, R; Cuello, M; Arellano, A; Florensa, R; Rosell, R.
Afiliação
  • Balaña, C; Institut Català d'Oncologia, Germans Trias i Pujol. Badalona. Spain
  • Capellades, J; Hospital Germans Trias i Pujol. Badalona. Spain
  • Teixidor, P; Hospital Germans Trias i Pujol. Badalona. Spain
  • Roussos, I; Institut Català d'Oncologia, Germans Trias i Pujol. Badalona. Spain
  • Ballester, R; Institut Català d'Oncologia, Germans Trias i Pujol. Badalona. Spain
  • Cuello, M; Institut Català d'Oncologia, Germans Trias i Pujol. Badalona. Spain
  • Arellano, A; Hospital Germans Trias i Pujol. Badalona. Spain
  • Florensa, R; Hospital Germans Trias i Pujol. Badalona. Spain
  • Rosell, R; Institut Català d'Oncologia, Germans Trias i Pujol. Badalona. Spain
Clin. transl. oncol. (Print) ; 9(12): 797-803, dic. 2007. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-123395
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

INTRODUCTION:

'Biopsy-only' high-grade glioma (HGG) patients get limited benefit from post-operative treatments, and as a group, negatively impact median survival outcomes. MATERIAL AND

METHODS:

We retrospectively evaluated clinical characteristics, treatment and overall survival of HGG patients with a 'biopsy- only' surgical approach diagnosed between 1997 and 2005 at a University Hospital in Spain.

RESULTS:

In 31% of 294 suspected gliomas, only a diagnostic biopsy was undertaken. Reasons for 'biopsy-only' for all patients were either location in eloquent areas (motor area 18.7%, language area 25,3%, basal ganglia 7.7%, visual area 4.4%) or extension of the disease (corpus callosum invasion 14.3% and multicentricity/multifocality 28.6%). Seventy-four patients (80.4%) were HGG 26% of all grade IV and 49% of all grade III tumours. For these patients, post-operative Karnofsky Performance Status of over 70%, median age and median survival were, respectively 64 and 70%, 60.7 and 57 years old, and 23.1 and 42.7 weeks (p=0.0006). Patients lived longer if post-operative treatment was given, in all grades (p<0.0001). Nineteen patients (25.6%) died within 42 days after surgery. Only 60% of them initiated radiotherapy and 10% of them did not complete it. However, tumour grade, radiotherapy and temozolomide- based chemotherapy were independently associated with longer survival in multivariate analysis (p<0.05).

CONCLUSION:

Almost one third of HGG patients can undergo only a biopsy and not debulking surgery. Although radiotherapy improves survival, only 50% of them complete the treatment. An individualised approach to these patients is needed to facilitate a correct analysis of therapy results. New therapies must be investigated in these patients (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2007 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Germans Trias i Pujol/Spain / Institut Català d'Oncologia, Germans Trias i Pujol/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2007 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Germans Trias i Pujol/Spain / Institut Català d'Oncologia, Germans Trias i Pujol/Spain
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