Hereditary pancreatic cancer: molecular bases and their application in diagnosis and clinical management: a guideline of the TTD group
Clin. transl. oncol. (Print)
; 14(8): 553-563, ago. 2012.
Artigo
em Inglês
| IBECS
| ID: ibc-126951
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Pancreatic carcinoma (PC) represents the fourth leading cause of cancer death in Spain with a death rate of 2,400 males and 2,000 females per year. Poor outcome related to its silent nature and the lack of reliable secondary prevention measures translate into advanced-stage diagnosis, 75 % of deaths within the first year of diagnosis and 5-year survival rate of <5 %. Family history was first recognized as a risk factor for PC. Further population-based and case-control studies subsequently found that 7.8 % of patients with PC have a family history of the same tumor and individuals with a first-degree relative with PC have a 3.2-fold increased risk of developing PC. Overall, it is estimated that up to 10 % of PC have a familial component. However, known genetic syndromes account for <20 % of the observed familial aggregation of PC. We review the most important aspects in epidemiology, molecular biology and clinical management of familial PC (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Neoplasia Pancreática
Base de dados:
IBECS
Assunto principal:
Neoplasias Pancreáticas
/
Lesões Pré-Cancerosas
/
Carcinoma
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Guia de prática clínica
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Clinical Hospital San Carlos/Spain
/
Hospital Ramón y Cajal/Spain
/
Hospital Reina Sofía/Spain
/
Hospital San Pau/Spain