Specific genetic polymorphisms of IL 10-592 AA and IL 10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients
Clin. transl. oncol. (Print)
; 15(4): 331-334, abr. 2013. tab
Artigo
em Inglês
| IBECS
| ID: ibc-127226
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
AIM:
This study was designed to explore the genetic polymorphism of IL-10 (-1082A/G, -592A/C, -819T/C), TNF-α (-308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients.METHODS:
The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom.RESULTS:
AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI (P = 0.005, OR = 3.137). No differences of TNF gene polymorphism between the two groups were seen.CONCLUSION:
The genetic polymorphism of the IL10-592A/C AA genotype and IL10-819T/C TT genotype was predominantly conferred to the incidence of docetaxel-induced liver injury (AU)
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Coleções:
Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama Masculina
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Beijing Chaoyang Hospital/China
/
Capital Medical University Cancer Center/China
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Capital Medical University Cancerr Center/China
/
Duke University Medical Center/Usa
/
Peking University Cancer Hospital/China