Unsuspected gallbladder carcinonma discovered during or after cholecystectomy: focus on appropriate radical re-resection according to the T-stage
Clin. transl. oncol. (Print)
; 15(8): 652-658, ago. 2013. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-127482
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
The long-term survival of patients with unsuspected gallbladder carcinoma (UGC) and the role of radical re-resection for this disease remain unclear.METHODS:
A retrospective study was carried out on 38 UGC patients. The time-to-event data were demonstrated by Kaplan-Meier curves. Comparing survival curves of two groups using the log-rank test.RESULTS:
The overall incidence of UGC in patients underwent cholecystectomy in our hospital was 0.18 % (25 of 14,073). Distribution according to actual pT-stage (the UICC) was pT1a n = 3; pT1b n = 11; pT2 n = 4; pT3 n = 12; pT4 n = 8. The preoperative diagnosis included a high rate of acute biliary tract inflammation (24 of 38, 63.2 %). Compared with other gallbladder carcinoma patients, UGC group had significantly higher proportion of early stages (pT1) (36.8 %, 14 of 38 cases) (p < 0.01), and better prognosis. The comparison of radical re-resection versus simple cholecystectomy showed a significant benefit in overall survival for the pT3 group (22.0 ± 5.48 vs. 5.0 ± 0.9 months; p = 0.02). There are median survival differences between the two subgroups of patients with pT1b tumors whether received re-resection or not. Median survival was 62.0 months and 24.0 ± 8.5 months, respectively, though the differences are not statistically significant (p = 0.131).CONCLUSION:
Radical re-resection is strongly recommended for patients with pT1b-stage cancer. The reoperation should be performed as soon as possible, preferably within 10 days after the initial operation (AU)
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Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Vesícula Biliar
Tipo de estudo:
Ensaio clínico controlado
/
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
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Humanos
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Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Central South University/China