Oropharyngeal cancer related to Human Papilloma Virus: incidence and prognosis in Madrid, Spain
Clin. transl. oncol. (Print)
; 16(3): 301-306, mar. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-127738
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
PURPOSE:
To report the incidence of HPV-related oropharyngeal cancer (OC) in our region, and determine the influence of HPV status on survival among patients treated with chemoradiation (CRT).METHODS:
A total of 102 patients with stage II-IV OC treated by CRT at four hospitals in Madrid, Spain were retrospectively reviewed. Immunohistochemistry analysis was performed to evaluate p16 expression in pretreatment tumor block samples obtained from these patients. HPV-positive and HPV-negative patients were compared to assess differences in overall survival (OS), loco-regional control and disease-free survival.RESULTS:
Of the tumor samples evaluated, 26.7 % were p16 positive. HPV-positive patients were younger (median age, 56 vs 59 years; p = 0.052). No significant differences were observed in terms of tumor stage, gender, or smoking habit between HPV+ and HPV- patients. HPV+ patients showed a trend towards better OS (67.4, vs 49.7 %; hazard ratio, 0.55; p = 0.095).CONCLUSIONS:
Incidence of HPV-related OC in our region is similar to that reported in other regions in Europe, yet lower than in North America. We observed a trend for improved OS in patients with HPV+ oropharyngeal cancer (AU)RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Neoplasias Bucais e Orofaríngeas
Base de dados:
IBECS
Assunto principal:
Neoplasias Orofaríngeas
/
Infecções por Papillomavirus
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hopsital Universitario Ramón y Cajal/Spain
/
Hospital Universitario Doce de Octubre/Spain
/
Hospital Universitario Puerta de Hierro/Spain
/
Hospital de la Princesa/Spain