Effects of localmelatonin application on post-extraction sockets after third molar surgery. A pilot study
Med. oral patol. oral cir. bucal (Internet)
; 19(6): e628-e633, nov. 2014. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-130359
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
OBJECTIVES:
The purpose of this study was to assess the anti-inflammatory, analgesic and osteogenic early effects of melatonin on post-extraction sockets of patients requiring third molars extraction. StudyDESIGN:
A randomized, triple-blind clinical trial was made using a split-mouth design. Both lower third molars of 10 patients were extracted and 3 mg of local melatonin or placebo were applied. Concentrations of interleukin-6 and nitrotyrosine were determined on samples of the clot from the socket by independent ELISA tests. Radiographic bone density was evaluated by measuring Hounsfield Units in panoramic and cross sections obtained by digital scanner. Statistycal analysis by Kolmogorov-Smirnov test was performed for ELISA data. Bone density was analyzed by Shapiro-Wilk test. Subsequently t test was applied. P<0.05 was considered to be significant.RESULTS:
The concentration of interleukin-6 increased with the application of melatonin without statistically below to the detectability pattern (<0.001 nM) in Optic Density curve. Bone density in panoramic sections at socket after melatonin application showed no significant difference (561.98 ± 105.92 HU vs 598.82 ± 209.03 HU). In cross sections, bone density in the alveolar region showed no significant difference(377.42 ± 125.67 HU vs 347.56 ± 97.02 HU).CONCLUSIONS:
Within the limitations of this pilot study, no differences with the application of melatonin were found in terms of the concentration of interleukin-6 and bone density in post-extraction socket of retained mandibular third molars
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Extração Dentária
/
Melatonina
/
Dente Serotino
Tipo de estudo:
Ensaio clínico controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complutense University of Madrid/Spain