Challenge test to bisphosphonates in patients with hypersensitivity reactions to drugs
Allergol. immunopatol
; 43(2): 127-130, mar.-abr. 2015.
Artigo
em Inglês
| IBECS
| ID: ibc-134677
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Bisphosphonates are a commonly used class of drugs with known efficacy in the prevention and treatment of postmenopausal and steroid-induced osteoporosis, Paget's disease of bone, hypercaelcemia of malignancy, osteolytic lesions of multiple myeloma, and bone metastases. Nitrogen-containing bisphosphonates have a favourable tolerability and safety profile, cutaneous reactions have been reported.METHODS:
This is a retrospective case series study, based on the analysis of data from 1429 patients admitted to the Allergy and Clinical Immunology Division of the University of Messina between January 2011 and December 2012. Most patients had previous adverse drug reactions (ADRs) and referred to us for a challenge test with an alternative drug. esults We observed six patients with a past history of adverse drug reaction who needed to be tested for bisphosphonates three patients for risedronate, two for clodronate and one for alendronate. In two years only two patients were referred to us for an adverse reaction to bisphosphonates one to alendronate and one to risedronate. Another patient presented a previous reaction to strontium ranelate. The other three patients reported previous hypersensitivity reactions to at least two different classes of drugs. All the patients experienced no reaction using the tested drugs.CONCLUSIONS:
In our experience drug challenge tests for bisphosphonates are safe and reliableRESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
IBECS
Assunto principal:
Urticária
/
Osteoporose Pós-Menopausa
/
Hipersensibilidade a Drogas
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Angioedema
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Messina/Italy
/
University of messina/Italy