Sjögrens syndrome of the oral cavity. Review and update
Med. oral patol. oral cir. bucal (Internet)
; 14(7): e325-e330, jul. 2009. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-136377
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Sjögren ́s syndrome is one of the most frequent autoimmune diseases. It is a chronic and systemic disorder pre- dominantly found in women, and is characterized by the appearance of a lymphocytic inflammatory infiltrate, with dryness of the oral cavity and eyes, secondary to involvement of the salivary and lacrimal glands. The under- lying causal mechanism involves a number of factors and has not been clearly established, though an autoimmune response is known to be triggered, with the accumulation of immune complexes in the gland acini that interfere with gland function. In the oral cavity, xerostomia or hyposialia is the most disabling manifestation for patients, and is accompanied by rapidly progressing caries, candidiasis and an important worsening of buccodental health. The most important complication is a 44-fold increase in the risk of developing non-Hodgkin lymphoma, com- pared with the general population. The treatment of Sjögrens syndrome is limited to symptomatic management, and involves the use of solutions to replace salivary secretion and afford a measure of hydration, cholinergic agents such as pilocarpine to stimulate the unaffected gland tissue and, recently, the administration of substances that act against surface antigens of the B lymphocytes, such as anti-CD20 and anti-CD22 antibodies. The present study provides an update on this disease, placing special emphasis on its odontologic implications (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Síndrome de Sjogren
/
Doenças da Boca
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital General Universitario de Valencia/Spain