Genome-wide association studies (GWAS) and their importance in asthma
Allergol. immunopatol
; 43(6): 601-608, nov-dic. 2015. tab
Artigo
em Inglês
| IBECS
| ID: ibc-145507
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Asthma is a complex disease determined by the interaction of different genes and environmental factors. The first genetic investigations in asthma were candidate gene association studies and linkage studies. In recent years research has focused on association studies that scan the entire genome without any prior conditioning hypothesis:
the so-called genome-wide association studies (GWAS). The first GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1). None of these genes would have been selected in a classical genetic association study since it was not known they could be implicated in asthma. To date, a number of GWAS studies in asthma have been made, with the identification of about 1000 candidate genes. Coordination of the different research groups in international consortiums and the application of new technologies such as new generation sequencing will help discover new implicated genes and improve our understanding of the molecular mechanisms underlying the diseaseRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Asma
/
Cromossomos Humanos Par 17
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Genômica
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Proteínas de Membrana
/
Proteínas de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
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Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complejo Asistencial Universitario de Salamanca/Spain
/
Hospital Universitario de Salamanca/Spain
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Instituto Biosanitario de Salamanca (IBSAL)/Spain
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Universidad de Salamanca/Spain