Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis
Allergol. immunopatol
; 44(2): 125-130, mar.-abr. 2016. tab
Artigo
em Inglês
| IBECS
| ID: ibc-150659
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR. MATERIALS ANDMETHODS:
Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method.RESULTS:
A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL-10 gene were found with higher frequencies in patients than controls. Patients with CC genotype in rs1800871 in Il-10 had significantly lower levels of IgE.CONCLUSION:
We found that certain genetic variants in IL-10 and TGF-β polymorphisms were associated with susceptibility to AR as well as some clinical parameters in the patients with ARRESUMEN
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Espanha
Base de dados:
IBECS
Assunto principal:
Interleucina-10
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Polimorfismo de Nucleotídeo Único
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Fator de Crescimento Transformador beta1
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Rinite Alérgica
Tipo de estudo:
Fatores de risco
Limite:
Criança
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Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Iran University of Medical Science/Iran
/
Kurdistan University of Medical Sciences/Iran
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Tehran University of Medical Sciences/Iran
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Universal Scientific Education and Research Network (USERN)/Iran