Histopathological grading systems analysis of oral squamous cell carcinomas of young patients
Med. oral patol. oral cir. bucal (Internet)
; 21(3): e285-298, mayo 2016. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-152708
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
To analyze the clinicopathological profile of young patients (ˇÜ 40 years) with oral SCC and correlate with a control group (ˇÝ 50 years) by means of histopathological grading systems. MATERIAL ANDMETHODS:
14 young patients and 14 control patients were selected with similar clinical stage and tumor location. Demographic and clinical data were obtained from patient records and histological sections were evaluated according to four histopathological grading systems. Associations between categories of demographic and clinical data were performed through Chi-square test and Exact Fisher test. The survival analyzes were performed according to the Kaplan-Meier method.RESULTS:
The comparison between groups showed a greater association of treatment modalities in younger patients (p = 0.022), they had a higher incidence of local recurrence and regional metastasis (p = 0.018) and lower disease free survival in 5 years (p = 0.069). There was no difference in 5-year overall survival among the studied groups. There was no difference in histological grading between studied groups according to the four used systems.CONCLUSIONS:
This study showed that, despite tumors had similar histological grade and more therapeutic modalities were used in the young group, tumors in young patients had a higher incidence of recurrence/metastasis, showing tendency to a more aggressive behavior
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Anatomic Pathology Laboratory (APC)/Brazil
/
Anatomic Pathology to Laboratoy (ANATOM)/Brazil
/
Oncology Center of Cascavel (CEONC)/Brazil
/
University of Campinas/Brazil
/
União Oeste Paranaense de Estudos e Combate ao Câncer (UOPECCAN) - Cancer Hospital/Brazil
/
Western Parana State University/Brazil