Molecular biology of testicular germ cell tumors
Clin. transl. oncol. (Print)
; 18(6): 550-556, jun. 2016. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-152749
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men. They constitute a unique pathology because of their embryonic and germ origin and their special behavior. Genetic predisposition, environmental factors involved in their development and genetic aberrations have been under study in many works throughout the last years trying to explain the susceptibility and the transformation mechanism of TGCTs. Despite the high rate of cure in this type of tumors because its particular sensitivity to cisplatin, there are tumors resistant to chemotherapy for which it is needed to find new therapies. In the present work, it has been carried out a literature review on the most important molecular aspects involved in the onset and development of such tumors, as well as a review of the major developments regarding prognostic factors, new prognostic biomarkers and the possibility of new targeted therapies (AU)
RESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
IBECS
Assunto principal:
Prognóstico
/
Neoplasias Testiculares
/
Cisplatino
/
Seminoma
/
Neoplasias Embrionárias de Células Germinativas
/
Perfilação da Expressão Gênica
/
Biologia Molecular
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Universitario Fundacion Alcorcón/Spain
/
Hospital Universitario Infanta Sofia/Spain
/
The Institute of Cancer Research/UK