Multiple opportunistic fungal infections in an individual with severe HIV disease: a case report / Múltiples infecciones fúngicas oportunistas en un individuo con enfermedad grave por VIH. Informe de un caso
Rev. iberoam. micol
; 33(2): 118-121, abr.-jun. 2016. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-153955
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
Background. Fungal infections have been commonly diagnosed in individuals with advanced HIV disease. Cryptococcosis, pneumocystosis, and histoplasmosis are the most frequent systemic mycoses in people suffering from HIV/AIDS. Case report. We report a case of multiple fungal infections in an advanced AIDS-patient. A 33-year-old HIV-positive man from Brazil was hospitalized due to diarrhea, dyspnea, emaciation, hypoxemia, extensive oral thrush, and a CD4+ T lymphocyte count of 20 cells/mm3. Honeycombed-structures consistent with Pneumocystis jirovecii were observed by direct immunofluorescence in induced sputum. Cryptococcus neoformans was recovered from respiratory secretion and cerebrospinal fluid cultures. Histopathology of the bone marrow also revealed the presence of Histoplasma capsulatum. Molecular assays were performed in a sputum sample. Nested-PCR confirmed the presence of P. jirovecii and H. capsulatum; qPCR multiplex was positive for C. neoformans and H. capsulatum. With the treatment of antifungal drugs the patient progressed satisfactorily. Conclusions. The diagnosis of several systemic mycoses demonstrates the vulnerability of advanced AIDS-patients. Thus, the detection of AIDS cases in the early stages of infection is necessary for a prompt and adequate introduction of HAART therapy, and the use of prophylaxis to control opportunistic infections (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Diarreia
/
Pneumonía
Base de dados:
IBECS
Assunto principal:
Pneumonia por Pneumocystis
/
Infecções Oportunistas Relacionadas com a AIDS
/
Síndrome Inflamatória da Reconstituição Imune
/
Histoplasmose
/
Antifúngicos
Limite:
Criança
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. iberoam. micol
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundação Oswaldo Cruz (Fiocruz)/Brazil
/
Instituto de Salud Carlos III/España