Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: Relevance for diagnosis of primary immunodeficiencies
Allergol. immunopatol
; 44(6): 571-579, nov.-dic. 2016. graf, tab
Artigo
em Inglês
| IBECS
| ID: ibc-157880
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Peripheral blood B cells include lymphocytes at various stages of differentiation, each with a specific function in the immune response. All these stages show variations in percentage and absolute number throughout human life. The numbers and proportions of B subpopulation are influenced by factors such as gender, age, ethnicity, and lifestyle. This study establishes reference values according to age of peripheral blood B cell subtypes in healthy Mexican population.METHODS:
Peripheral blood from healthy new-borns and adults were analysed for total B cell subpopulations, using surface markers such as CD19, IgM, IgD, CD21, CD24, CD27, and CD38, to identify naïve, memory with and without isotype switch, double-negative, transitional, and plasmablast cells.RESULTS:
We observed a significant variation in terms of frequency and absolute counts between all groups analysed. Values from each B cell subpopulation show variations according to age.CONCLUSIONS:
In order to attempt to elucidate reference values for B cell subpopulation, the present study evaluated a population sample of healthy blood donors from this region. Values reported here can also be used as a tool for diagnosis of diseases in which B cell maturation is affectedRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Imunodeficiência de Variável Comum
/
Síndromes de Imunodeficiência
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Nacional de Pediatría/México
/
Instituto Politécnico Nacional (IPN)/México
/
Instituto Politécnico Nacional/México