Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer
Clin. transl. oncol. (Print)
; 19(6): 651-657, jun. 2017. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-162822
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. These miRNAs are expressed in the cells and are also present in cell-derived extracellular vesicles such as exosomes. Exosomes have been shown to act as mediators for cell to cell communication because of the regulatory functions of their content. High levels of exosomes are found in several body fluids from cancer patients and could be a potential source of non-invasive biomarkers. In this review, we summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Próstata
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Biópsia
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Biomarcadores
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MicroRNAs
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Exossomos
Tipo de estudo:
Estudo prognóstico
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Estudo de rastreamento
Limite:
Humanos
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Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Antwerp University Hospital/Belgium
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Antwerp University/Belgium
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Hospital General Universitario de Valencia/Spain
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Institute of Biosciences and BioResources/Italy