Serum periostin is not related to asthma predictive index
Allergol. immunopatol
; 46(3): 235-240, mayo-jun. 2018. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-172942
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
In contrast to adult asthmatic patients, studies on the role of serum periostin levels in schoolchildren with asthma are still conflictive, and very few studies have been performed in pre-schoolers. The aim of this study was to compare serum periostin levels in recurrent wheezer pre-schoolers according to their asthma predictive index (API) condition.METHODS:
We performed a case-control study enrolling pre-schoolers with recurrent wheezing episodes (>3 episodes confirmed by physician) presented at one paediatric clinic in Santiago, Chile. The population was divided according to stringent API criteria into positive or negative.RESULTS:
In a one-year period, 60 pre-schoolers were enrolled. After excluding 12 (due to not fulfilment of inclusion criteria or refusal of blood sample extraction), 48 remaining pre-schoolers (27 males, age range from 24 to 71 months) completed the study; 34 were API positive and 14 were API negative. There were no significant differences in demographics between groups. The level of serum periostin levels for pre-schoolers with positive API and negative API were (median 46.7 [25.5-83.1] and 67.5 [20.5-131.8], p = 0.9, respectively). The area under the curve for the serum periostin levels for predict positive API was 0.5, 95% CI [0.29-0.70], p = 0.9. No significant correlation between serum periostin levels and peripheral blood eosinophils was found.CONCLUSION:
Serum periostin levels were no significantly different between wheezer pre-schoolers with positive and negative API. More studies are needed to confirm thisfinding:
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Asma
/
Biomarcadores
/
Moléculas de Adesão Celular
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/Chile