Are endometrial cancer radiotherapy results age related?
Clin. transl. oncol. (Print)
; 20(11): 1416-1421, nov. 2018. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-173732
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objective:
To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. Materials andmethods:
From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups Group-1 202 patients < 65 years; Group-2 210 patients ≥ 65 and < 80 years; Group-3 26 patients ≥ 80 years. Vaginal toxicity was assessed using the objective LENT-SOMA criteria and RTOG scores were recorded for the rectum, bladder, and small bowel. Statistics Chi square and Students t tests, Kaplan-Meier survival study for analysis of CSS.Results:
The mean follow-up was 5.6 years in Group-1, 5.6 years in Group-2 and 6.3 years in Group-3 (p = 0.38). No differences were found among the groups in distribution of stage, grade, myometrial invasion, Type 1 vs. 2 EC and VLSI (p = 0.97, p = 0.52, p = 0.35, p = 0.48, p = 0.76, respectively). There were no differences in rectal, bladder and vagina late toxicity (p = 0.46, p = 0.17, p = 0.75, respectively). A better CSS at 5 years was found in Group-1 (p = 0.006), and significant differences were found in late severe small bowel toxicity in Group-3 (p = 0.005). VCR was increased in Group-3 (p = 0.017).Conclusions:
Patients ≥ 65 years had a worse outcome in comparison to younger patients. Late vaginal, rectal and bladder toxicities were similar in the three groups, although an increase of severe late small bowel toxicity led to IMRT in patients ≥ 80 years. Further larger studies are needed including quality of life analysis in patients ≥ 80 yearsRESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Lesões por Radiação
/
Radioterapia
/
Neoplasias do Endométrio
Aspecto:
Preferência do paciente
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Clinic Universitari/Spain
/
Hospital Clínic Universitari/Spain
/
Hospital General de Albacete/Spain
/
Hospital Sant Joan de Reus/Spain
/
University of Barcelona/Spain