Periodontal treatment on patients with cardiovascular disease: Systematic review and meta-analysis
Med. oral patol. oral cir. bucal (Internet)
; 23(6): e681-e690, nov. 2018. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-176390
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development.OBJECTIVE:
To analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. MATERIAL ANDMETHODS:
A systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017.RESULTS:
Ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval 1.100-1.299, p < 0.001; and mean difference 0,79 g/L, 95% confidence interval 0.717-0.879, p < 0.001, respectively).CONCLUSIONS:
Periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatmentRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doença Cardiovascular
/
Condições e Transtornos Bucais
Base de dados:
IBECS
Assunto principal:
Doenças Periodontais
/
Doenças Cardiovasculares
Tipo de estudo:
Ensaio clínico controlado
/
Revisão sistemática
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
University Hospital of Bellvitge/Spain
/
University of Barcelona/Spain