E-Cadherin gene expression in oral cancer: Clinical and prospective data
Med. oral patol. oral cir. bucal (Internet)
; 24(4): e444-e451, jul. 2019. tab, ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-185657
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown whether low expression of E-cadherin is also present at the mRNA level in OSCC cases.Objective:
The aim of this study was to compare E-cadherin mRNA expression in OSCC patients and controls and to correlate the expression with clinical and prospective characteristics. Material andMethods:
Forty patients and 40 controls were enrolled. E-cadherin mRNA expression was evaluated by quantitative real-time polymerase chain reaction using TaqMan probes.Results:
E-cadherin mRNA expression was significantly decreased in OSCC patients compared to that of controls (p < 0.001). Whereas no significant association between clinical parameters and E-cadherin expression levels was observed, we noted lower E-cadherin expression levels in patients with positive lymph node metastasis.Conclusions:
E-cadherin mRNA expression was markedly diminished in OSCC, in agreement with previous re-sults that examined E-cadherin expression at the protein level. E-cadherin is downregulated in the early clinical stages of OSCC, and its mRNA levels do not change significantly in the advanced stages, suggesting that there is limited usefulness of this parameter for predicting disease progressionRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad Autónoma Metropolitana/México
/
Universidad Autónoma de Zacatecas/México
/
Universidad Juárez del Estado de Durango/México
/
Universidad de Guadalajara/México
/
Universidad de la Republica/Uruguay
/
Universidad de la República/Uruguay