Assessment of vitamin D status in common variable immunodeficiency or ataxia-telangiectasia patients
Allergol. immunopatol
; 47(5): 499-505, sept.-oct. 2019. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-186525
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Introduction and objectives:
Vitamin D plays a role in the immune system, however studies regarding this are scarce. This study aimed to evaluate the nutritional status of vitamin D in patients with Common Variable Immunodeficiency (CVID) or Ataxia-Telangiectasia (A-T) and to relate it to body composition, inflammatory and bone metabolism markers. Patients andmethods:
This is a cross-sectional and controlled study involving 24 patients of both sexes (59.3% male), aged 8-56 years, with CVID (n = 15) or A-T (n = 9). The following variables were evaluated body mass index (BMI), 25-hydroxyvitamin D (25 (OH) D), hepatic profile, parathormone, calcium, phosphorus, alkaline phosphatase, interleukin 6 and high-sensitivity C-reactive protein.Results:
The median age was 26.0 years. A deficiency of 25 (OH) D was found in four A-T patients (44%) and two CVID patients (13%). Nine patients with CVI (60%) and six with A-T (66.7%) were overweight and underweight, respectively. There was a negative correlation between vitamin D and fat mass in the CVID group, and vitamin D and BMI in the A-T group. Vitamin D was negatively associated with the percentage of total fat among the patients (β - 0.842, 95% CI -1.5-0.17, p = 0.015), R2 = 0.21, after adjusting for sex and age.Conclusion:
Vitamin D deficiency occurred in a quarter of the patients although there was no difference between the patient and the control group; without association with bone and inflammation biomarkers. The percentage of fat and BMI were negatively associated with the concentrations of 25 (OH) DRESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Hormônio Paratireóideo
/
Vitamina D
/
Ataxia Telangiectasia
/
Imunodeficiência de Variável Comum
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
ABC Faculty of Medicine/Brazil
/
Federal University of Alfenas/Brazil
/
Federal University of São Paulo/Brazil