Comparative study of overweight and obese patients with nonalcoholic fatty liver disease
Rev. esp. enferm. dig
; 111(4): 256-263, abr. 2019. tab
Artigo
em Inglês
| IBECS
| ID: ibc-189921
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background and aims:
non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the western world. Although NAFLD prevalence is higher in patients with a BMI > 25 kg /m2, it is unclear if there are differences between overweight and obese patients. The associated biochemical, dietary and genetic parameters were compared between overweight and obese patients with NAFLD.Methods:
patients with biopsy-proven NAFLD (n = 203) were enrolled in a cross-sectional study. The MEDAS questionnaire was used to assess adherence to the Mediterranean diet. Biochemical, anthropometrical parameters and the I148M variant (rs738409) of the PNPLA3 gene and rs180069 of the TNF-alfa gene were evaluated.Results:
overweight patients had higher serum adiponectin levels (22.5 +/- 21.9 vs 11.2 +/- 18.1 ng/ml; p < 0.05) and lower resistin (3.3 +/- 1.7 vs 8.1 +/- 8 ng/ml; p < 0.001) and leptin concentrations (22.9 +/- 21.9 vs 55.8 +/- 45 ng/ml; p < 0.001) than obese patients. Non-alcoholic steatohepatitis (NASH) was more frequent in the obese group (59.3% vs 41.3%; p = 0.02). The multivariate analysis showed adherence to the Mediterranean diet to be an independent protective factor for NASH and liver fibrosis in overweight patients (OR 0.7, 95% CI 0.5-0.8).Conclusions:
NASH was more prevalent in obese patients than in overweight subjects. HOMA-IR and adherence to the Mediterranean diet provided protection against fibrosis in overweight patients. Adherence to the Mediterranean diet was the only independent factor associated with NASH in these patientsRESUMEN
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Coleções:
Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Síndrome Metabólica
/
Fígado Gorduroso
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Hepatopatia Gordurosa não Alcoólica
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundación Hospital Alcorcón/Spain
/
Hospital Clínico Universitario/Spain
/
Universidad de Valladolid/Spain