Heart failure: the importance of getting the right cause
Galicia clin
; 81(2): 51-53, abr. 2020. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-195198
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Amyloidosis is a systemic disease, with an incidence of 5-12 people per million per year. Autopsy studies suggest a higher incidence1. Is characterized by deposition of amyloid fibrils in extracellular tissue of various organs and systems, and therefore with multiple possible presentations. The causative amyloid fibril deposits are of monoclonal light chain (AL) or transthyretin (TTR) in most cases. TTR amyloidosis may be acquired, associated with wild type TTR or hereditary (associated with variants in TTR gene2 (table 1).The AL amyloidosis condition can occur alone or associated with multiple myeloma or other B-cell dyscrasias3. The main affected organs in AL amyloidosis are the heart, kidney, liver, gastrointestinal tract and the peripheral and autonomic nervous systems. Patients often present with non-specific symptoms, such as asthenia, weight loss, palpitations and syncopal attacks4. Thus, diagnosis is usually delayed, and renal and cardiac failure can be forms of pres-entation. We report a case of a 68-year-old woman, who presented with new onset heart failure as the main presentation form of multiple myeloma with associ-ated cardiac amyloidosis. This case highlights the need of a high level of suspicion in order establish an early diagnosis and initiate specific therapy, and therefore delay the development of this condition
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Amiloidose de Cadeia Leve de Imunoglobulina
/
Insuficiência Cardíaca
/
Mieloma Múltiplo
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Galicia clin
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Beatriz Ângelo/Portugal
/
Hospital de Santa Maria/Portugal