Evaluation of patients with primary immunodeficiency associated with Bacille Calmette-Guerin (BCG)-vaccine-derived complications
Allergol. immunopatol
; 48(6): 729-737, nov.-dic. 2020. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-199264
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Bacille Calmette-Guerin (BCG) vaccination has a great impact on the prevention of severe complications of tuberculosis. However, in patients with primary immunodeficiencies (PID), it can lead to severe complications such as severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial disease. This study highlights the demographics, clinical complications and laboratory parameters among PID patients associated with BCG vaccination side effects.METHODS:
One hundred and thirty-seven PID patients with BCGosis were evaluated in this study, based on the complications following BCG vaccination.RESULTS:
The mean age of the patients with BCG complications at the time of the first visit was five years. The within-group comparison of patients showed a highly significant incidence of pneumonia and hepatomegaly in severe combined immunodeficiency patients. Furthermore, the immunologic data showed an increase in the overall rates of lymphocytes such as CD3+, CD4+ and CD8 + T cells in Mendelian susceptibility to mycobacterial disease patients. The level of immunoglobulins has also increased in chronic granulomatous disease patients.CONCLUSION:
The high rate of undiagnosed PIDs predisposes individuals to a high risk of severe side effects as a result of BCG vaccination, as well as infants that are less than one month of age. Therefore, there is a need for early screening and diagnosis of PIDs before exposing unknown PID status patients to BCG vaccination. The benefits of screening and early diagnosis of PID cannot be overemphasized, especially in patients with a previous family history of immunodeficiencyRESUMEN
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Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Vacina BCG
/
Síndromes de Imunodeficiência
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
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Feminino
/
Humanos
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Lactente
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Alborz University of Medical Sciences/Iran
/
College of Medical Sciences, Ahmadu Bello University/Nigeria
/
Iran University of medical sciences/Iran
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Tehran University of Medical Sciences/Iran
/
Universal Scientific Education and Research Network (USERN)/Iran
/
University of Medical Science/Iran