Antibodydrug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance
Clin. transl. oncol. (Print)
; 24(3): 407-431, marzo 2022. graf
Artigo
em Inglês
| IBECS
| ID: ibc-203538
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
An antibodydrug conjugate (ADC) is an advanced chemotherapeutic option with immense promises in treating many tumor. They are designed to selectively attack and kill neoplastic cells with minimal toxicity to normal tissues. ADCs are complex engineered immunoconjugates that comprise a monoclonal antibody for site-directed delivery and cytotoxic payload for targeted destruction of malignant cells. Therefore, it enables the reduction of off-target toxicities and enhances the therapeutic index of the drug. Hepatocellular carcinoma (HCC) is a solid tumor that shows high heterogeneity of molecular phenotypes and is considered the second most common cause of cancer-related death. Studies show enormous potential for ADCs targeting GPC3 and CD24 and other tumor-associated antigens in HCC with their high, selective expression and show potential outputs in preclinical evaluations. The review mainly highlights the preclinical evaluation of different antigen-targeted ADCs such as MetFab-DOX, Anti-c-Met IgG-OXA, Anti CD 24, ANCHN-01, G7mab-DOX, hYP7-DCand hYP7-PC, Anti-CD147 ILs-DOX and AC133-vcMMAF against hepatocellular carcinoma and its future relevance.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Carcinoma
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Carcinoma Hepatocelular
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Avaliação Pré-Clínica de Medicamentos
/
Anticorpos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
AIMS Health Science Campus/India
/
AIMS Health Science Campus,/India
/
Amrita Institute of Medical Sciences and Research Centre/India