The role of liver kinase B1 in tumor progression through regulation of lipid metabolism
Clin. transl. oncol. (Print)
; 24(11): 2045-2054, noviembre 2022.
Artigo
em Inglês
| IBECS
| ID: ibc-210133
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
The somatic mutation of liver kinase B1 (LKB1) has been implicated in various tumors, which is reflected in the survival, proliferation, and metastasis of tumor cells. However, the regulation of LKB1 in lipid metabolism, a process that is involved in tumor progression is not completely clear. We conclude that LKB1 deficiency results in abnormal expression and activation of multiple molecules related to lipid metabolism which locate downstream of AMP-activated protein kinase (AMPK) or salt-induced kinase (SIK). Abnormal lipid metabolism induced by LKB1 deficiency contributes to the proliferation and metastasis of tumor cells through energy regulation. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Quinases de Proteína Quinase Ativadas por Mitógeno
/
Proteínas Quinases Ativadas por AMP
/
Metástase Neoplásica
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Jilin University/China