Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19
J. investig. allergol. clin. immunol
; 31(2): 94-107, 2021. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-215182
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health and disease status. Classically, eosinophils have been considered important immune cells in the pathogenesis of inflammatory processes (eg, parasitic helminth infections) and allergic or pulmonary diseases (eg, asthma) and are always associated with a type 2 immune response. Furthermore, in recent years, eosinophils have been linked to the immune response by conferring host protection against fungi, bacteria, and viruses, which they recognize through several molecules, such as toll-like receptors and the retinoic acidinducible gene 1like receptor. The immune protection provided by eosinophils is exerted through multiple mechanisms and properties. Eosinophils contain numerous cytoplasmatic granules that release cationic proteins, cytokines, chemokines, and other molecules, all of which contribute to their functioning. In addition to the competence of eosinophils as effector cells, their capabilities as antigen-presenting cells enable them to act in multiple situations, thus promoting diverse aspects of the immune response. This review summarizes various aspects of eosinophil biology, with emphasis on the mechanisms used and roles played by eosinophils in host defence against viral infections and response to vaccines. The review focuses on respiratory viruses, such as the new coronavirus, SARS-CoV-2. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Mastocitose
/
Vacinas Sintéticas
/
Infecções por Coronavirus
/
Coronavírus Relacionado à Síndrome Respiratória Aguda Grave
/
Anafilaxia
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. investig. allergol. clin. immunol
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundación Jiménez Díaz/Spain