Hypoxia: molecular pathophysiological mechanisms in human diseases
J. physiol. biochem
; 78(4): 739-752, nov. 2022. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-216168
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Hypoxia, a low O2 tension, is a fundamental feature that occurs in physiological events as well as pathophysiological conditions, especially mentioned for its role in the mechanism of angiogenesis, glucose metabolism, and cell proliferation/survival. The hypoxic state through the activation of specific mechanisms is an aggravating circumstance commonly noticed in multiple sclerosis, cancer, heart disease, kidney disease, liver disease, lung disease, and in inflammatory bowel disease. On the other hand, hypoxia could play a key role in tissue regeneration and repair of damaged tissues, especially by acting on specific tissue stem cells, but their features may result as a disadvantage when it is concerned for neoplastic stem cells. Furthermore, hypoxia could also have a potential role in tissue engineering and regenerative medicine due to its capacity to improve the performance of biomaterials. The current review aims to highlight the hypoxic molecular mechanisms reported in different pathological conditions to provide an overview of hypoxia as a therapeutic agent in regenerative and molecular therapy. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Pneumopatias
/
Hipóxia
Limite:
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
"Ss. Annunziata" Hospital/Italy
/
Karpagam Academy of Higher Education/India
/
University "G. d'Annunzio" Chieti-Pescara/Italy