Monotherapy versus polytherapy of enoxaparin and hydroxychloroquine for the treatment of COVID-19: A randomized controlled clinical trial
Pharm. pract. (Granada, Internet)
; 21(1): 1-7, ene.-mar. 2023. graf, tab
Artigo
em Inglês
| IBECS
| ID: ibc-218475
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Objectives:
The current study aims to assess the efficacy and safety of Enoxaparin and hydroxychloroquine (HCQ) used as monothrapy or polytherapy versus standard care alone in Coronavirus 2019 (COVID-19) infected patients.Methods:
The current study included two hundred patients with laboratory confirmed COVID-19 infection. Patients admitted to hospital were randomly allocated into four groups group I received standard COVID-19 therapy, group II received Enoxaparin 40mg/day subcutaneously (SC) plus standard therapy, group III received 400 mg/day HCQ plus standard therapy & group IV received a combination of 400 mg/day HCQ and Enoxaparin plus standard COVID-19 therapy. The disease progression was evaluated by duration to a negative polymerase chain reaction (PCR), length of hospital or Intensive Care Unit (ICU) stay, and mortality rate. The safety of treatments was evaluated by measuring adverse effects.Results:
The length of hospital stay, ICU admission and mortality were significantly decreased in Enoxaparin plus standard COVID-19 therapy group versus other groups.Conclusion:
These findings suggest that Enoxaparin was safe, effective, and well tolerated and has a role in decreasing the progression of the disease and its complications while HCQ did not discover any evidence of extra therapeutic benefits. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Infecções por Coronavirus
/
Pandemias
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Pharm. pract. (Granada, Internet)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
Al Ain University/Abu Dhabi
/
Beni-Suef University/Egypt
/
October 6 University/Egypt