Hereditary angioedema in children and adolescents
Allergol. immunopatol
; 50(SP1): 1-6, 08 abr. 2022. tab
Artigo
em Inglês
| IBECS
| ID: ibc-219075
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Family history can help with the diagnosis; however, approximately 25% of the cases are de novo mutations. Biochemical diagnosis should be delayed until after 1 year of age. Children were often excluded from advances in therapy for hereditary angioedema since most of the new medicines were tested in adults and thus excluded by the Food and Drug Administration (FDA) and other agencies for approval to be used in children. Treatment of attacks is available for the pediatric patient; however, barriers still exist for the use of long-term prophylaxis in young children. © 2022 Codon Publications. Published by Codon Publications (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Proteína Inibidora do Complemento C1
/
Angioedemas Hereditários
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Centro Universitario FMABC/Brazil
/
Penn State University/USA
/
University of California San Diego/USA
/
University of Campinas/Brazil