Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis
Med. oral patol. oral cir. bucal (Internet)
; 28(4)jul. 2023. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-222285
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Osteonecrosis of the jaw (ONJ) has a frequent adverse effect after the administration of nitrogenous bisphosphonates, as non-nitrogenous bisphosphonates are metabolized more rapidly and would produce this effect to a lesser extent. The objective of this study is to analyze the results obtained in the literature with the use of L-PRF in the treatment of ONJ through a systematic review and meta-analysis. Material andmethods:
Medline (via PubMed), Cochrane, Web of Science and Grey Literature Database was screened from which 10 were selected.Results:
In the meta-analysis with full resolution, combining the use of L-PRF in the treatment of ONJ, a weighted proportion (PP) of 94.3% of complete resolution is obtained (95% CI 91.2-97.4, p<0.001), with a low degree of heterogeneity, statistically significant (I2 = 29.02%; p<0.001). When analyzing the non-resolution data, a weighted proportion (PP) of 7.7% (95% CI 3.6-11.9; p<0.001) was obtained with moderate heterogeneity (I2 41.87%; p=0.112). In the meta-regression, no significant correlation was found between complete resolution and year of publication (intercept = 2.88, p=0.829). In consistency analysis no major changes in PP are identified when any of the studies are eliminated, demonstrating a high reliability in the combined results.Conclusion:
L-PRF alone or in combination with other therapies in treatment of ONJ achieved high percentages of complete lesion resolution (94.3%). In studies where L-PRF is combined with other therapies, and where the effectiveness of the other therapy alone is analyzed, L-PRF has been shown higher percentages of resolution. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos
/
Fibrina Rica em Plaquetas
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
A.C. Camargo Cancer Center/Brazil
/
Department of Functional Biology and Health Sciences University of Vigo/Spain
/
Federal University of Sergipe/Brazil
/
UNIFAMINAS/Brazil
/
University of Santiago de Compostela/Spain