Relationship between HuR and tumor drug resistance
Clin. transl. oncol. (Print)
; 25(7): 1999-2014, jul. 2023. ilus
Article
em En
| IBECS
| ID: ibc-222374
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Human resistance protein R (HuR), also known as embryonic lethal abnormal visual-like protein (ELAVL1), is an RNA-binding protein widely expressed in vivo that affects the mRNA stability of targeted and is involved in post-transcriptional regulation. Recent studies have shown that HuR is aberrantly expressed in different human cancers and is an essential factor in poor clinical prognosis. The role of HuR in numerous tumors suggests that it could be a new target for tumor therapy and as a marker for efficacy and prognostic assessment. This review focuses on the relationship between HuR and drug resistance in different tumors and briefly describes the structure, function, and inhibitors of HuR. We summarize the mechanisms by which HuR causes tumor resistance and the molecular targets affected (AU)
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Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Resistencia a Medicamentos Antineoplásicos
/
Proteína Semelhante a ELAV 1
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2023
Tipo de documento:
Article