The Tol-Pal system of Acinetobacter baumannii is important for cell morphology, antibiotic resistance and virulence / El sistema Tol-Pal de Acinetobacter baumannii es importante para la morfología celular, la resistencia a los antibióticos y la virulencia
Int. microbiol
; 26(3): 543-550, Ene-Agos, 2023. graf, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-223980
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Acinetobacter baumannii is an opportunistic human pathogen that has become a global threat to healthcare institutions. This Gram-negative bacterium is one of the most successful human pathogens worldwide and responsible for hospital-acquired infections. This is due to its outstanding potential to adapt to very different environments, to persist in the human host and most important, its ability to develop multidrug resistance. Our combined approach of genomic and phenotypic analyses led to the identification of the envelope spanning Tol-Pal system in A. baumannii. We found that the deletion of the tolQ, tolR, tolA, tolB, and pal genes affects cell morphology and increases antibiotic sensitivity, such as the ∆tol-pal mutant exhibits a significantly increased gentamicin and bacitracin sensitivity. Furthermore, Galleria mellonella caterpillar killing assays revealed that the ∆tol-pal mutant exhibits a decreased killing phenotype. Taken together, our findings suggest that the Tol-Pal system is important for cell morphology, antibiotic resistance, and virulence of A. baumannii.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Virulência
/
Resistência Microbiana a Medicamentos
/
Acinetobacter baumannii
/
Fatores de Virulência
/
Forma do Núcleo Celular
Limite:
Humanos
Idioma:
Inglês
Revista:
Int. microbiol
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
Advanced Light and Electron Microscopy ZBS4/Germany
/
Goethe-University Frankfurt Am Main/Germany