PMS2: a potential prognostic protein marker in oral squamous cell carcinoma / PMS2: un potencial marcador proteico de pronóstico en el carcinoma oral de células escamosas
Med. oral patol. oral cir. bucal (Internet)
; 26(4): e451-e458, Juli. 2021. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-224589
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
An increase in oral squamous cell carcinoma (OSCC) cases was observed despite the reduction inexposure to classic risk factors. Although the exact cause of this trend remains unknown, epigenetic factors couldbe contributing to an increased occurrence of these tumors. This study aims to assess the influence of PMS2 pro-tein immunoexpression on the prognosis of patients with OSCC.Material andMethods:
This study comprised 76 cases of OSCC treated between 2011 and 2016. Immunohisto-chemical staining for PMS2 was performed. For evaluation, 10 fields per histological section were photographed ata 400x magnification and positively-stained cells were counted with Image J. Mann-Whitney and Kruskal-Wallistests were used to compare the immunolabeling pattern with the clinical-pathological and prognostic characteris-tics. Survival analysis was performed with Chi-square, Long-Rank Mantel-Cox and Cox regression tests (p<0.05).Results:
An overexpression of PMS2 was observed in N0/1 tumors and in oral cancers found in unusual locations.In patients ≤60 years of age, high levels of PMS2 (>60%; p=0.041) were associated with low survival (p=0.029).In multivariate analysis, surgery combined with chemotherapy (p=0.030) and high PMS2 immunoexpression(p=0.042) significantly increased the risk of death for ≤60 years old patientsConclusions:
The findings of this study indicate that PMS2 can be a potential prognostic protein marker in OSCCpatients 60 years of age and younger.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
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Endonuclease PMS2 de Reparo de Erro de Pareamento
/
Neoplasias de Cabeça e Pescoço
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of Ceará/Brazil
/
Hospital Haroldo Juaçaba/Brazil
/
Unichristus/Brazil