A Genome-Wide Association Study of Small Cell Lung Cancer
Arch. bronconeumol. (Ed. impr.)
; 59(10): 645-650, oct. 2023. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-226192
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Introduction:
Small cell lung cancer (SCLC) comprises 1015% of all lung cancer cases and is the most aggressive histological type. Survival is poor and the molecular landscape of this disease is extraordinarily complex. The objective of this paper was to perform a Genome-Wide Association Study (GWAS) of this disease using a casecontrol study specifically designed for small cell lung cancer (SCLC).Methods:
Incident cases were consecutively recruited from 8 hospitals from different regions of Spain. Controls were recruited from the same hospitals using a frequency sampling based on age and sex distribution of cases. Biological samples were obtained along with detailed information on cases and controls lifestyle, including tobacco and radon exposure.Results:
We included 271 SCLC cases and 557 controls. We found evidence (p-values<10−5) of an association in the complete dataset for several loci, while MAP4 showed a significant association in the gene-based analysis. Pathway analysis suggested that ATR, ATRIP, MCM4, MCM5, ORC4, RPA3 and CDC25A genes have a role on the onset of SCLC.Conclusion:
This study provides biological evidence for pathways related to SCLC, offering novel loci for further research. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Carcinoma de Pequenas Células do Pulmão
/
Neoplasias Pulmonares
Limite:
Humanos
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Arch. bronconeumol. (Ed. impr.)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
Brown University/USA
/
Fundación Pública Galega de Medicina Xenómica/Spain
/
Puerta de Hierro Majadahonda University Hospital/Spain
/
Universidade de Santiago de Compostela/Spain
/
University of Santiago de Compostela/Spain