Prostate Cancer: Management of Biochemical Recurrence after Surgery
Arch. esp. urol. (Ed. impr.)
; 76(10): 755-763, diciembre 2023. tab
Artigo
em Inglês
| IBECS
| ID: ibc-229533
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Radical prostatectomy (RP) is one of the primary treatment options for localised prostate cancer (PCa). Despite its curativeintent, 1/3 of patients will experience biochemical recurrence (BCR) during follow-up. Experts have devoted efforts to associatethe influence of each individual factor with the risk of BCR to select the optimal treatment for each patient. Optimal managementmust aim to find a balance between delaying the onset of metastatic disease and overtreating an indolent disease with treatmentsthat can affect quality of life of the patients. Thus far, effective treatment options for men with BCR remain controversial interms of ideal treatment timing (adjuvant vs. salvage), radiotherapy (RT) fields and doses, selection and duration of systemictherapy and potential synergies between treatments and their therapeutic sequencing. Next-generation imaging techniques, suchas Prostate-Specific Membrane Antigen Positron Emission Tomography, are used for early detection of disease progression andexact site of recurrence or progression, thereby enhancing decision making for future disease management. In this review, weevaluate available evidence of controversial topics regarding BCR after RP and explore future directions, such as prognosticand/or predictive factors of response, genetic panels, second-generation hormone treatments, ultra-hypofractionated RT andongoing clinical trials in this clinical scenario. (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Prostatectomia
/
Neoplasias da Próstata
/
Adjuvantes Imunológicos
Limite:
Humanos
Idioma:
Inglês
Revista:
Arch. esp. urol. (Ed. impr.)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
GenesisCare/Spain
/
Genesiscare/UK
/
Gregorio Marañón Universitary Hospital/Spain
/
Ramon y Cajal Universitary Hospital/Spain
/
Virgen de la Victoria Hospital/Spain