Effect of Intravenous Injection of Remazolam on Stress Response and Analgesic Effect in Patients with Transurethral Resection of the Prostate: A Single-Centre Study

ABSTRACT

Background: The reasonable selection of anaesthesia methods and drugs is the key to ensuring the perioperative safety of patientswith the transurethral resection of the prostate (TURP). The effect of intravenous remazolam injection on stress response andanalgesic effect in patients with transurethral prostate cancer electrotomy were explored.Methods: The medical records of 160 patients with prostatic hyperplasia who underwent TURP in Tianjin hospital from November2020 to November 2022 were selected for retrospective analysis. Five patients who did not meet the study conditions wereexcluded, and 155 patients were finally included. According to anaesthesia schemes, the patients were divided into the observationgroup (OBG, n = 76, routine surgical anaesthesia and intravenous remazolam injection) and control group (COG, n = 79,routine surgical anaesthesia). Postoperative eye-opening times were recorded for both groups. The groups were compared interms of anaesthetic effects, stress indexes, haemodynamic indexes, and use of postoperative analgesic drugs at different times,and adverse reactions were observed.Results: The anaesthesia onset time and eye-opening time in the OBG were shorter than those in the COG (p < 0.001). The heartrate and mean arterial pressure of the OBG during anaesthesia induction were higher than those in the COG (p < 0.001). TheOBG showed significantly lower noradrenaline and cortisol levels than the COG 1, 12 and 24 h after surgery (p < 0.001). Thetime of first pressing in the analgesic pump in the OBG was later than that in the COG, and the total consumption of sufentanil was less than that in the COG (p < 0.001). The total incidence of adverse reactions in the OBG was lower than that in the COG(p < 0.05). (AU)