Volume of the Dentate Gyrus/CA4 Hippocampal subfield mediates the interplay between sleep quality and depressive symptoms / El volumen del subcampo del giro dentado/hipocampo CA4 media la interacción entre la calidad del sueño y los síntomas depresivos
Int. j. clin. health psychol. (Internet)
; 24(1): [100432], Ene-Mar, 2024. tab, ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-230372
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Emerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus might play a crucial role in the interplay between sleep disturbance and depressive symptomatology, e.g., hippocampal atrophy is typically seen in both insomnia disorder and depression. Thus, examining the role of hippocampal volume in the interplay between poor sleep quality and depressive symptoms in large healthy populations is vital.Methods:
We investigated the association between self-reported sleep quality, depressive symptoms, and hippocampal total and subfields volumes in 1603 healthy young adults from the Behavioral Brain Research Project. Mediation analysis explored the mediating role of hippocampal volumes between sleep quality and depressive symptoms.Results:
Self-reported sleep quality and depressive symptoms were positively correlated. In addition, it negatively related to three hippocampal subfields but not total hippocampal volume. In particular, hippocampal subfield DG and CA4 volumes mediated the interrelationship between poor sleep quality and depressive symptoms.Conclusions:
Our findings improved the current understanding of the relationship between sleep disturbance, depressive symptomatology, and hippocampal subfields in healthy populations. Considering the crucial role of DG in hippocampal neurogenesis, our results suggest that poor sleep quality may contribute to depression through a reduction of DG volume leading to impaired neurogenesis which is crucial for the regulation of mood.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Psicologia Clínica
/
Giro Denteado
/
Giro Para-Hipocampal
/
Depressão
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. j. clin. health psychol. (Internet)
Ano de publicação:
2024
Tipo de documento:
Artigo
Instituição/País de afiliação:
Heinrich-Heine-Universität Düsseldorf/Germany
/
Southwest University/China